Osteoporosis is a metabolic bone disease which degrades a bone microstructure and therefore increases bone fragility. Osteoporotic fractures result in decreased quality of life as well as excessive financial costs. If the morphological changes of a bone structure can be estimated and diagnosed, osteoporosis can be properly managed with clinical treatments.
This research develops a topology optimization-based bone remodeling simulation which can reflect the morphological changes in a bone structure over time. Note that topology optimization is mathematically matched well with phenomenological bone remodeling simulation. Topology optimization determines the optimal bone structure under a given loading condition by iteratively redistributing mass in a design domain. The proposed method can contribute to the development of early diagnosis for osteoporosis and patient-specific models for various clinical purposes.
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